An explanation for the long duration of mydriatic effect of atropine in eye
作者： P N Patil , M Salazar
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摘要: The mydriatic effect of topically applied 3H-atropine (2%) was compared in the pigmented rabbits (black fur and dark brown irides) nonpigmented (albino) atropinesterase-negative rabbits. duration, t1/2, rabbit 43.5 greater than 96 hours, respectively. At hour 96, tissue iris that by factor eight. longer duration is explained slow release bound drug from pigment onto muscarinic receptors.
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