Disposition of pilocarpine in the pigmented rabbit eye
作者： Vincent H.L. Lee , Joseph R. Robinson
DOI: 10.1016/0378-5173(82)90051-5
关键词: Corneal permeability 、 Aqueous humor 、 Drug concentration 、 Pilocarpine 、 Pharmacology 、 Anesthesia 、 Drug accumulation 、 Rabbit (nuclear engineering) 、 Drug supply 、 Cornea 、 Chemistry 、 Pharmaceutical Science
摘要: Abstract The disposition of pilocarpine in the pigmented rabbit eye following instillation a solution was studied using radiotracer techniques. results suggest that topically applied removed as efficiently from tear chamber albino rabbit. Nevertheless, larger fraction dose recovered eye, possibly due to combined effect improved corneal permeability, metabolism drug cornea, and binding iris-ciliary body. Based on area under concentration vs time curve, about 10 times much found body than Despite this accumulation body, which presumably derived its supply aqueous humor, humor virtually indistinguishable
elsevier.com
sci-hub.se 参考文章(18)
J R Robinson, V H Lee, H W Hui, Corneal metabolism of pilocarpine in pigmented rabbits. Investigative Ophthalmology & Visual Science. ,vol. 19, pp. 210- 213 ,(1980)
P N Patil, M Salazar, An explanation for the long duration of mydriatic effect of atropine in eye Investigative Ophthalmology & Visual Science. ,vol. 15, pp. 671- 673 ,(1976)
Sono Yoshida, Saiichi Mishima, A pharmacokinetic analysis of the pupil response to topical pilocarpine and tropicamide Japanese Journal of Ophthalmology. ,vol. 19, pp. 121- 138 ,(1975)
James W. Sieg, Joseph R. Robinson, Mechanistic Studies on Transcorneal Permeation of Pilocarpine Journal of Pharmaceutical Sciences. ,vol. 65, pp. 1816- 1822 ,(1976) , 10.1002/JPS.2600651230
Yoel Kloog, Dan I. Sachs, Amos D. Korczyn, David S. Heron, Mordechai Sokolovsky, Muscarinic acetylcholine receptors in cat iris. Biochemical Pharmacology. ,vol. 28, pp. 1505- 1511 ,(1979) , 10.1016/0006-2952(79)90465-9
Hernán Valenzuela, Christa Maria Schedtler, Hans Reinhard Koch, Otto Hockwin, Phenol oxidase activity of the iris and the ciliary body in rats. Graefes Archive for Clinical and Experimental Ophthalmology. ,vol. 201, pp. 207- 212 ,(1977) , 10.1007/BF02385177
James W. Sieg, Joseph R. Robinson, Vehicle Effects on Ocular Drug Bioavailability I: Evaluation of Fluorometholone Journal of Pharmaceutical Sciences. ,vol. 64, pp. 931- 936 ,(1975) , 10.1002/JPS.2600640606
Harrout E. Melikian, Theodore W. Lieberman, Irving H. Leopold, Ocular Pigmentation and Pressure and Outflow Responses to Pilocarpine and Epinephrine American Journal of Ophthalmology. ,vol. 72, pp. 70- 73 ,(1971) , 10.1016/0002-9394(71)91592-3
Jonathan S. Lyons, David L. Krohn, Pilocarpine Uptake by Pigmented Uveal Tissue American Journal of Ophthalmology. ,vol. 75, pp. 885- 888 ,(1973) , 10.1016/0002-9394(73)90898-2
Vincent H.-L. Lee, Kim W. Morimoto, Robert E. Stratford, Esterase distribution in the rabbit cornea and its implications in ocular drug bioavailability. Biopharmaceutics & Drug Disposition. ,vol. 3, pp. 291- 300 ,(1982) , 10.1002/BDD.2510030402