Determinants of iron accumulation in the normal aging brain

摘要: In a recent postmortem study, R-2* relaxometry in gray matter (GM) of the brain has been validated as noninvasive measure for iron content tissue. Iron accumulation normal aging is common finding and relates to maturation degeneration. The goal this study was assess determinants during aging. cohort consisted 314 healthy community-dwelling participants Austrian Stroke Prevention Study. Their age ranged from 38-82 years. Quantitative magnetic resonance imaging performed on 3T included mapping, based 3D multi-echo gradient echo sequence. median values measured all GM regions, which were segmented automatically using FreeSurfer. We investigated 25 possible cerebral deposition. These demographics, volume, lifestyle factors, cerebrovascular risk serum levels iron, single nucleotide polymorphisms related regulating genes (rs1800562, rs3811647, rs1799945, rs1049296). body mass index (BMI) significantly 15/32 analyzed regions with strongest correlations found amygdala (p = 0.0091), medial temporal lobe 0.0002), hippocampus <= 0.0001). Further associations deep smoking. No significant gender, or iron-associated genetic polymorphisms. conclusion, besides age, BMI smoking are only normally subjects. Smoking deposition basal ganglia, whereas higher associated neocortex following an Alzheimer-like distribution. (C) 2016 ELSEVIER. All rights reserved.