The synergetic effect of bioactive ceramic and nanoclay on the properties of chitosan–gelatin/nanohydroxyapatite–montmorillonite scaffold for bone tissue engineering
作者： Ali Olad , Fahimeh Farshi Azhar
DOI: 10.1016/J.CERAMINT.2014.04.010
关键词:
摘要: Abstract The objective of this study was to develop a novel composite scaffold based on chitosan–gelatin/nanohydroxyapatite–montmorillonite (CS–Gel/nHA–MMT) with improved properties for use in tissue engineering applications. This prepared via freeze–drying technique, using the ice particulates as porogen material. characterized Fourier transform infrared spectroscopy (FT-IR), x-ray diffraction (XRD) and scanning electron microscopy (SEM) techniques. highly porous pore size 100–350 μm. In addition, synergetic effect nHA MMT physicochemical including swelling ratio, density, biodegradation, mechanical behaviors were studied. bioactivity carried out simulated body fluid solution (SBF) followed by characterization SEM. Scaffolds presence showed decreased degradation rate increased biomineralization. Also good porosity characters caused its properties. From results it can be concluded that introducing matrix creates controllable condition moderate which is useful bone
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