Pattern of humoral immune response to Plasmodium falciparum blood stages in individuals presenting different clinical expressions of malaria
作者： Fabiana MS Leoratti , Rui R Durlacher , Marcus VG Lacerda , Maria G Alecrim , Antonio W Ferreira
关键词:
摘要: Background: The development of protective immunity against malaria is slow and to be maintained, it requires exposure multiple antigenic variants parasites age-associated maturation the immune system. Evidence that associated with different classes subclasses antibodies reveals importance considering quality response. In this study, we have evaluated humoral response Plasmodium falciparum blood stages individuals naturally exposed who live in endemic areas Brazil order assess prevalence specific isotypes their association clinical expressions. Methods: Different P. stages, IgG, IgG1, IgG2, IgG3, IgG4, IgM, IgE IgA, were determined by ELISA. results based on analysis expressions (complicated, uncomplicated asymptomatic) factors related prior such as age number previous attacks. occurrence H131 polymorphism FcγIIA receptor was also investigated part studied population. Results: highest levels IgG2 IgG3 observed asymptomatic malaria, while IgM predominant among complicated malaria. Individuals reporting more than five attacks presented a predominance antibodies, IgA predominated or less Among there high-avidity low-avidity antibodies. found 44.4% individuals, allele, suggesting role Conclusion: Together, suggest differential regulation anti-P. antibody pattern showed even unstable transmission areas, can observed, when appropriated are produced.
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H Groux, J Gysin, Opsonization as an effector mechanism in human protection against asexual blood stages of Plasmodium falciparum: functional role of IgG subclasses. Research in Immunology. ,vol. 141, pp. 529- 542 ,(1990) , 10.1016/0923-2494(90)90021-P
Salah E. Farouk, Amagana Dolo, Sàndor Bereczky, Bourema Kouriba, Boubacar Maiga, Anna Färnert, Hedvig Perlmann, Masashi Hayano, Scott M. Montgomery, Ogobara K. Doumbo, Marita Troye-Blomberg, Different antibody- and cytokine-mediated responses to Plasmodium falciparum parasite in two sympatric ethnic tribes living in Mali Microbes and Infection. ,vol. 7, pp. 110- 117 ,(2005) , 10.1016/J.MICINF.2004.09.012
A. Nasr, N. C. Iriemenam, M. Troye-Blomberg, H. A. Giha, H. A. Balogun, O. F. Osman, S. M. Montgomery, G. ElGhazali, K. Berzins, Fc gamma receptor IIa (CD32) polymorphism and antibody responses to asexual blood-stage antigens of Plasmodium falciparum malaria in Sudanese patients Scandinavian Journal of Immunology. ,vol. 66, pp. 87- 96 ,(2007) , 10.1111/J.1365-3083.2007.01947.X
Naomi W Lucchi, Jon Eric Tongren, Vidhan Jain, Avinash C Nagpal, Christian W Kauth, Ute Woehlbier, Hermann Bujard, Aditya P Dash, Neeru Singh, Jonathan K Stiles, Venkatachalam Udhayakumar, None, Antibody responses to the merozoite surface protein-1 complex in cerebral malaria patients in India. Malaria Journal. ,vol. 7, pp. 121- 121 ,(2008) , 10.1186/1475-2875-7-121
Kazuya Omi, Jun Ohashi, Jintana Patarapotikul, Hathairad Hananantachai, Izumi Naka, Sornchai Looareesuwan, Katsushi Tokunaga, Fcγ receptor IIA and IIIB polymorphisms are associated with susceptibility to cerebral malaria Parasitology International. ,vol. 51, pp. 361- 366 ,(2002) , 10.1016/S1383-5769(02)00040-5
John P Manis, Ming Tian, Frederick W Alt, Mechanism and control of class-switch recombination Trends in Immunology. ,vol. 23, pp. 31- 39 ,(2002) , 10.1016/S1471-4906(01)02111-1
D. Kwiatkowski, I. Sambou, P. Twumasi, B.M. Greenwood, A.V.S. Hill, K.R. Manogue, A. Cerami, J. Castracane, D.R. Brewster, TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria. The Lancet. ,vol. 336, pp. 1201- 1204 ,(1990) , 10.1016/0140-6736(90)92827-5
Georges Snounou, Suganya Viriyakosol, William Jarra, Sodsri Thaithong, K.Neil Brown, Identification of the four human malaria parasite species in field samples by the polymerase chain reaction and detection of a high prevalence of mixed infections Molecular and Biochemical Parasitology. ,vol. 58, pp. 283- 292 ,(1993) , 10.1016/0166-6851(93)90050-8
Magdalena Plebanski, Adrian VS Hill, The immunology of malaria infection. Current Opinion in Immunology. ,vol. 12, pp. 437- 441 ,(2000) , 10.1016/S0952-7915(00)00117-5
Thoraya M E A-Elgadir, Mustafa I. Elbashir, Klavs Berzins, Emad M. Masuadi, Ishraga E A-Elbasit, Gehad ElGhazali, Hayder A. Giha, The profile of IgG-antibody response against merozoite surface proteins 1 and 2 in severe Plasmodium falciparum malaria in Eastern Sudan Parasitology Research. ,vol. 102, pp. 401- 409 ,(2008) , 10.1007/S00436-007-0777-3