Regulation of D-3 phosphoinositides during T cell activation via the T cell antigen receptor/CD3 complex and CD2 antigens.
作者： Stephen G. Ward , Steven C. Ley , Colin Macphee , Doreen A. Cantrell
关键词:
摘要: An immediate consequence of T cell activation via the receptor (TcR)/CD3 complex and CD2 antigen is hydrolysis phosphatidylinositol-(4,5)-bisphosphate generation inositol-(1,4,5)-trisphosphate diacylglycerol which then regulate intracellular calcium protein kinase C. Changes in cellular levels phosphoinositides phosphorylated on D-4 D-5 position during have been well documented. Recently it has proposed that D-3 inositol ring by a novel phosphoinositide (PI) 3 may also be important activation. In present study we examined regulation cells activated TcR/CD3 antigens. The data show existence phosphatidylinositol-(3)-monophosphate [PtdIns(3)P], phosphatidylinositol-(3,4)-bisphosphate [PtdIns(3,4)P2] phosphatidylinositol-(3,4,5)-trisphosphate [PtdIns(3,4,5)P3] cells. Activation or results modulation PtdIns(3,4)P2 putative PtdIns(3,4,5)P3 but does not change PtdIns(3)P. These provide first evidence lipid products PI exist
sci-hub.se 参考文章(37)
E G Lapetina, R D Nolan, Thrombin stimulates the production of a novel polyphosphoinositide in human platelets. Journal of Biological Chemistry. ,vol. 265, pp. 2441- 2445 ,(1990) , 10.1016/S0021-9258(19)39818-7
J Downward, S Rayter, P Warne, J D Graves, D A Cantrell, M Glennie, A L Tutt, CD2 antigen mediated activation of the guanine nucleotide binding proteins p21ras in human T lymphocytes. Journal of Immunology. ,vol. 146, pp. 3709- 3712 ,(1991)
C L Carpenter, B C Duckworth, K R Auger, B Cohen, B S Schaffhausen, L C Cantley, Purification and characterization of phosphoinositide 3-kinase from rat liver. Journal of Biological Chemistry. ,vol. 265, pp. 19704- 19711 ,(1990) , 10.1016/S0021-9258(17)45429-9
T W Cunningham, D L Lips, V S Bansal, K K Caldwell, C A Mitchell, P W Majerus, Pathway for the formation of D-3 phosphate containing inositol phospholipids in intact human platelets. Journal of Biological Chemistry. ,vol. 265, pp. 21676- 21683 ,(1990) , 10.1016/S0021-9258(18)45793-6
G L Kucera, S E Rittenhouse, Human platelets form 3-phosphorylated phosphoinositides in response to alpha-thrombin, U46619, or GTP gamma S. Journal of Biological Chemistry. ,vol. 265, pp. 5345- 5348 ,(1990) , 10.1016/S0021-9258(19)39361-5
K Yamamoto, A Graziani, C Carpenter, L C Cantley, E G Lapetina, A novel pathway for the formation of phosphatidylinositol 3,4-bisphosphate. Phosphorylation of phosphatidylinositol 3-monophosphate by phosphatidylinositol-3-monophosphate 4-kinase. Journal of Biological Chemistry. ,vol. 265, pp. 22086- 22089 ,(1990) , 10.1016/S0021-9258(18)45672-4
M Kawata, A Kikuchi, M Hoshijima, K Yamamoto, E Hashimoto, H Yamamura, Y Takai, Phosphorylation of smg p21, a ras p21-like GTP-binding Protein, by Cyclic AMP-dependent Protein Kinase in a Cell-free System and in Response to Prostaglandin E1 in Intact Human Platelets Journal of Biological Chemistry. ,vol. 264, pp. 15688- 15695 ,(1989) , 10.1016/S0021-9258(19)84887-1
D L Lips, P W Majerus, F R Gorga, A T Young, T L Benjamin, Phosphatidylinositol 3-phosphate is present in normal and transformed fibroblasts and is resistant to hydrolysis by bovine brain phospholipase C II. Journal of Biological Chemistry. ,vol. 264, pp. 8759- 8763 ,(1989) , 10.1016/S0021-9258(18)81858-0
S G Ward, D A Cantrell, Heterogeneity of the regulation of phospholipase C by phorbol esters in T lymphocytes. Journal of Immunology. ,vol. 144, pp. 3523- 3528 ,(1990)
André Veillette, Michael A. Bookman, Eva M. Horak, Joseph B. Bolen, The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck Cell. ,vol. 55, pp. 301- 308 ,(1988) , 10.1016/0092-8674(88)90053-0