Drug-induced hepatotoxicity: 2005.

摘要: The removal from the marketplace of several widely prescribed drugs due to hepatotoxicity has attracted considerable attention. Now under extensive review are means by which we can better identify hepatic risk prior federal approval. Assessment risk-to-benefit ratios regarding a novel agent with issues (especially one for life-threatening condition) requires judgment and education on part prescribers patients. spectrum drug-induced liver injury is broad simulation almost all unknown disorders. Drug-induced injuries often have somewhat characteristic signature, as regards type (hepatocellular vs cholestatic) time onset. diagnosis exclusion initial suspicion based circumstantial evidence. Factors affecting susceptibility include age, sex, concomitant use other drugs, genetic polymorphism in metabolic pathways involved activation or disposition therapeutic drugs. Drug-drug interactions present particular problems patients, elderly, who receiving simultaneously. Mechanisms many varied. With intermediary products produced during metabolism highly reactive toxic. In these situations, balance between rate production metabolite effectiveness drug may determine whether not occurs.