Which is Safer to Avoid an Increase in ICP After Endotracheal Suctioning in Severe Head Injury: Intravenous or Endotracheal Lidocaine?

摘要: Background: In patients with severe head injury, endotracheal suctioning (ES) is a potentially unsafe procedure, because it can increase intracranial pressure (ICP) and decrease cerebral perfusion (CPP). Lidocaine has been shown to directly blunt ICP rises before ES, although not known whether the efficacy of lidocaine given endotracheally comparable that intravenously. The purpose this study was evaluated effects ES on or without use intravenously in trauma.  Methods: Twenty admitted intensive care unit having traumatic brain injury Glasgow Coma Scale ≤ 8 were evaluated. Patients randomly 1.5 mg/kg 2% (Group 1), 1 2) did receive 3) prior ES. ICP, mean arterial pressure, heart rate CPP monitored continuously recorded immediately after ES.  Results: There no significant group (P = 0.56) 2 0.06) patients. However, increased 3 0.0002).  Conclusions: Our findings suggest administration effectively prevents reduction trauma. Aiming for patient safety we propose intravenous drugs have heightened risk causing harm when used error preventable adverse drug events, are prominent quality cost issue healthcare. doi: http://dx.doi.org/10.4021/jnr201w