The complete genome sequence of the gastric pathogen Helicobacter pylori
作者： Jean-F. Tomb , Owen White , Anthony R. Kerlavage , Rebecca A. Clayton , Granger G. Sutton
DOI: 10.1038/41483
关键词:
摘要: Helicobacter pylori, strain 26695, has a circular genome of 1,667,867 base pairs and 1,590 predicted coding sequences. Sequence analysis indicates that H. pylori well-developed systems for motility, scavenging iron, DNA restriction modification. Many putative adhesins, lipoproteins other outer membrane proteins were identified, underscoring the potential complexity host-pathogen interaction. Based on large number sequence-related genes encoding presence homopolymeric tracts dinucleotide repeats in sequences, like several mucosal pathogens, probably uses recombination slipped-strand mispairing within as mechanisms antigenic variation adaptive evolution. Consistent with its restricted niche, few regulatory networks, limited metabolic repertoire biosynthetic capacity. Its survival acid conditions depends, part, ability to establish positive inside-membrane low pH.
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