Selective breeding for high alcohol preference increases the sensitivity of the posterior VTA to the reinforcing effects of nicotine.

摘要: The rate of codependency for alcohol and nicotine is extremely high. Numerous studies have indicated that there a common genetic association alcoholism dependency. current experiments examined whether selective breeding high preference in rats may be associated with increased sensitivity the posterior ventral tegmental area (pVTA) to reinforcing properties nicotine. In addition, can directly bind serotonin-3 (5-HT3 ) receptor, which has been shown mediate other drugs abuse within pVTA Wistar were assigned groups allowed self-infuse 0, 10, 50, 100, 200, 400 or 800 μM two-lever (active inactive) operant chambers. P 1, 50 100 μM Co-infusion 5-HT3 receptor antagonists into was also determined. self-infused at lower concentrations than required support self-administration rats. received more self-infusions rats; including 5HT3 antagonist (LY-278,584 zacopride) reduced responding on active lever. Overall, data an between suggest activation receptors maintain local actions pVTA.