Aerosolized genetic vaccines and methods of use

作者: Srinivas Rao , Charla Anne Andrews , Mario Roederer , Gary J. Nabel

DOI:

关键词:

摘要: The present invention generally features methods for the mucosal delivery of immunogenic compositions and treating or preventing diseases featuring such compositions. In particular embodiments, are genetic vaccines formulated as aerosols.

参考文章(17)
Olivier Vidalin, Gillian Margaret Baxter, Paul Andrew Hamblin, John Philip Tite, Karen A Barber, Sara Jane Brett, Method of eliciting immune response ,(2006)
Yashuhiko Koezuka, Gloria Gonzalez-Aseguinolaza, Moriya Tsuji, Use of glycosylceramides as adjuvants for vaccines against infections and cancer ,(2002)
Jun Wang, Lisa Thorson, Richard W Stokes, Michael Santosuosso, Kris Huygen, Anna Zganiacz, Mary Hitt, Zhou Xing, None, Single Mucosal, but Not Parenteral, Immunization with Recombinant Adenoviral-Based Vaccine Provides Potent Protection from Pulmonary Tuberculosis Journal of Immunology. ,vol. 173, pp. 6357- 6365 ,(2004) , 10.4049/JIMMUNOL.173.10.6357
Donna Montgomery, Jeffrey Ulmer, Margaret A. Liu, Kris Huygen, Polynucleotide tuberculosis vaccine ,(1995)
Daisy Vanrompay, Eric Cox, Pete Kaiser, Shelly Lawson, Marnix Van Loock, Guido Volckaert, Bruno Goddeeris, Protection of turkeys against Chlamydophila psittaci challenge by parenteral and mucosal inoculations and the effect of turkey interferon-gamma on genetic immunization. Immunology. ,vol. 103, pp. 106- 112 ,(2001) , 10.1046/J.1365-2567.2001.01215.X
Ajay Gautam, Charles L. Densmore, Bo Xu, J.Clifford Waldrep, Enhanced gene expression in mouse lung after PEI-DNA aerosol delivery. Molecular Therapy. ,vol. 2, pp. 63- 70 ,(2000) , 10.1006/MTHE.2000.0087
M BIVASBENITA, R ZWIER, H JUNGINGER, G BORCHARD, Non-invasive pulmonary aerosol delivery in mice by the endotracheal route. European Journal of Pharmaceutics and Biopharmaceutics. ,vol. 61, pp. 214- 218 ,(2005) , 10.1016/J.EJPB.2005.04.009
Patricia A Darrah, Dipti T Patel, Paula M De Luca, Ross W B Lindsay, Dylan F Davey, Barbara J Flynn, Søren T Hoff, Peter Andersen, Steven G Reed, Sheldon L Morris, Mario Roederer, Robert A Seder, Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major. Nature Medicine. ,vol. 13, pp. 843- 850 ,(2007) , 10.1038/NM1592
Ruth Arnon, Tamar Ben-Yedidia, Old and new vaccine approaches. International Immunopharmacology. ,vol. 3, pp. 1195- 1204 ,(2003) , 10.1016/S1567-5769(03)00016-X