Nebulizable tuberculosis vaccine for transnasal administration comprising paramyxovirus vector

作者: 哲哉 野阪 , 福村 正之 , 光雄 河野 , 康宏 保富

DOI:

关键词: VirologyGeneTuberculosisVector (molecular biology)Equivalent functionMycobacteriumTuberculosis vaccinesBiologyMycobacterium bovis

摘要: Disclosed is a nebulizable vaccine for transnasal administration, which has high prophylactic effect on human tuberculosis, particular adult tuberculosis. The tuberculosis administration comprises paramyxovirus gene (particularly rhPIV2) having, integrated therein, encoding an α-antigen derived from acid-fast bacterium (e.g., Mycobacterium kansaii or bovis BCG), analogue of the gene, variant equivalent function to that gene.

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