Prevalence and persistence of chromosomal damage and susceptible genotypes of metabolic and DNA repair genes in Chinese vinyl chloride-exposed workers.

摘要: Vinyl chloride (VC) was classified as a group 1 carcinogen by IARC in 1987. Although the relationship between VC exposure and liver cancer has been established, mechanism of VC-related carcinogenesis remains largely unknown. Previous epidemiological studies have shown that is associated with increased genotoxicity humans. To explore chromosomal damage its progression, their association to genetic susceptibility, we investigated 402 workers exposed VC, 77 VC-exposed cohort 141 unexposed subjects. We measured frequencies cytokinesis-block micronucleus (CBMN) reflect conducted genotyping for six xenobiotic metabolisms five DNA repair genes' polymorphism. Data indicate 95% control had CBMN ≤3‰, whereas 3.73-fold increase compared controls. Among who were followed from 2004 2007, mean frequency higher 2007 than ratio 2.08. Multiple Poisson regression analysis showed significantly elevated intermediate high groups low. Exposed CYP2E1 or XRCC1 variance wild-type homozygous counterparts, so did GSTP1 ALDH2 genotype. This study provides evidence cumulative dose common variants genes relevant detoxification carcinogens are major factors modulate induction workers.