In Vivo Photovoltaic Performance of a Silicon Nanowire Photodiode-Based Retinal Prosthesis.

摘要: Author(s): Bosse, Brandon; Damle, Samir; Akinin, Abraham; Jing, Yi; Bartsch, Dirk-Uwe; Cheng, Lingyun; Oesch, Nicholas; Lo, Yu-Hwa; Cauwenberghs, Gert; Freeman, William R | Abstract: Purpose:For more than 20 years, there has been an international, multidisciplinary effort to develop retinal prostheses restore functional vision patients blinded by degeneration. We developed a novel subretinal prosthesis with 1512 optically addressed silicon nanowire photodiodes, which transduce incident light into electrical stimulation of the remaining circuitry. This study was conducted evaluate efficacy driving produce visual cortex activation via retina. Methods:We measured electrically evoked potential responses (EEPs) in rabbit response illumination pulsed 852-nm infrared (IR) light. compared EEP visually (VEPs) 532-nm visible (positive control) and IR (negative control). Results:Activating devices produced significantly higher trough-to-peak amplitude (54.17 ± 33.4 μV) alone (24.07 22.1 or background cortical activity (23.22 17.2 μV). latencies were faster focal VEP latencies. Focal VEPs amplitudes (94.88 43.3 EEPs. also demonstrated how electrode placed on cornea can be used as noninvasive method monitor function implant. Conclusions:These results show that electrodes elicit EEPs cortex, providing evidence for viability prosthetic approach restoration.