Predictors of the progression of functional disability in patients with ankylosing spondylitis.

摘要: OBJECTIVE: To identify patient characteristics that predict the short term (5 yr) rate of progression functional disability in ankylosing spondylitis (AS). METHODS: In a prospective longitudinal study, 212 patients with AS reported information on health status biannual mailed questionnaires. The median duration followup was 5 yrs (range 1-7.5 yrs). Functional measured using Health Assessment Questionnaire for Spondyloarthropathies (HAQ-S; possible range 0-3). Predictors change HAQ-S over time included demographic characteristics, number comorbid conditions, age at onset AS, peripheral arthritis, smoking, body mass index, social support (measured by Interpersonal Support Evaluation List, ISEL), current and past physical activity work, recreational activity, severity pain stiffness, nonsteroidal antiinflammatory drug use, frequency back exercise. Associations between predictors (HAQ-S units/yr) were tested pooled series regression analysis. RESULTS: Patients mostly middle-aged (mean 48 yrs), male (70%), white (86%), well educated 15.5 an average 20 little study entry 0.66). Over yrs, increased 0.0168 units/yr. multivariate analyses, older (change slope +0.0007 units/yr age; p = 0.0008) smoking +0.0313 units/yr;