Seeing Is Believing: Nuclear Imaging of HIV Persistence

摘要: A major obstacle to HIV eradication is the presence of infected cells that persist despite suppressive antiretroviral therapy (ART). largely resides outside peripheral circulation, and thus, numerous anatomical lymphoid compartments have capacity harbor are inaccessible routine sampling. As a result, there limited understanding tissue burden infection or distribution transcriptional translational activity. Novel, non-invasive, in vivo methods urgently needed address this fundamental gap knowledge. In review, we discuss past current nuclear imaging approaches been applied with an emphasis on strategies implement positron emission tomography (PET)-based directly visualize characterize whole-body burden. These various limitations, such as potential for PET sensitivity specificity setting ART suppression low viral However, recent advances high-sensitivity, total-body platforms development new radiotracer technologies may enhance penetration target-specific tracer molecules discussed. Potential image non-viral markers focal immune perturbation also addressed. Overall, emerging techniques play important role novel therapeutic reservoir strategies.