Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes

摘要: Background Vitamin B6 plays vital roles in numerous metabolic processes the human body, such as nervous system development and functioning. It has been associated with some benefits non-randomised studies, higher Apgar scores, birthweights, reduced incidence of pre-eclampsia preterm birth. Recent studies also suggest a protection against certain congenital malformations. Objectives To evaluate clinical effects vitamin supplementation during pregnancy and/or labour. Search methods We searched Cochrane Pregnancy Childbirth Group Trials Register (31 March 2015) reference lists retrieved studies. Selection criteria We included randomised controlled trials comparing administration labour with: placebos, no supplementations, or supplements not containing B6. Data collection analysis Two review authors independently assessed for inclusion risk bias, extracted data checked them accuracy. For this update, we methodological quality using bias GRADE approach. Main results Four (1646 women) were included. The method randomisation was unclear all four allocation concealment reported only one trial. Two used blinding participants outcomes. Vitamin oral capsules lozenges resulted decreased dental decay pregnant women (capsules: ratio (RR) 0.84; 95% confidence interval (CI) 0.71 to 0.98; trial, n = 371, low evidence; lozenges: RR 0.68; CI 0.56 0.83; 342, evidence). A small trial showed mean birthweights (mean difference -0.23 kg; -0.42 -0.04; 33; trial). We did find any statistically significant differences eclampsia 1242; three trials; 944; trial), (capsules 1197; two trials, low-quality evidence) scores at minute (oral pyridoxine: 45; between supplemented non-supplemented groups. No found five minutes, breastmilk production controls receiving (n 24; trial) intramuscular loading doses pyridoxine labour. Overall, judged unclear. evidence both decay. other primary outcomes, birth before 37 weeks birthweight, trials. Authors' conclusions There few reporting outcomes mostly methodology inadequate follow-up. There is enough detect than suggesting Future assessing orofacial clefts, cardiovascular malformations, neurological development, birth, adverse events are required.