The urinary excretion of three C-21 methyl corticosteroids in the adrenogenital syndrome.

摘要: ABSTRACT Three of the more abundant C-21 methyl corticosteroids were measured in urine 11 patients (aged 2 weeks to 23 years) with adrenogenital syndrome, and compared excretion normal controls 4 cases virilizing adrenal adenomas. In all syndrome due congenital hyperplasia, there was an elevation urinary pregnanetriol (average, 0.29 mg. / Kg. day), 11-ketopregnanetriol (0.44 day) 17-hydroxypregnanolone day). controls, each steroid 0.01 day or less. No significant any 3 compounds observed adenoma. Urinary highest youngest patients, whom “salt-losers,” but not older child who also a “salt-loser”; thus disproportionate increase this single compound may be related age. The combined 17-OH-pregnanolone (products of...