Recent Advances in Human Steroid Metabolism

摘要: Publisher Summary This chapter discusses steroid metabolism that concern either recent developments in analytic techniques or interpretations of complex endocrine laboratory data. It is frequently pertinent to determine accurately the production rate (PR) a hormone. “Production rate” defined as sum glandular secretion particular hormone plus all other compounds contribute this metabolites measured. In past, PR has been approximated inferred from measurements urinary metabolite levels blood levels. The only approximate actual because unpredictable alterations metabolism, difficulties hydrolysis conjugates, and fact several precursors can yield same metabolites. an attempt relate rate, variations are produced by circadian rhythms metabolic clearance rate. Thus, attention shifted more direct measurement rates using isotopic methods.