N-CoR-HDAC Corepressor Complexes: Roles in Transcriptional Regulation by Nuclear Hormone Receptors
作者： P. L. Jones , Y.-B. Shi
DOI: 10.1007/978-3-642-55747-7_9
关键词:
摘要: Many nuclear hormone receptors (NHRs) actively repress the expression of their primary response genes through recruitment transcriptional corepressor complexes to regulated promoters. N-CoR and highly related SMRT were originally isolated characterized by ability interact exclusively with unliganded forms ofNHRs confer repression. Recently, both corepressors have been found exist in vivo multiple, distinct macromolecular complexes. While these differ overall composition, a general theme is that they contain histone deacetylase enzymatic activity. Several additional proteins functional ties chromatin structure. Together, data suggest modulation structure plays central role mediated repression from NHRs.
springer.com
core.ac.uk 
sci-hub.se 参考文章(101)
Y B Shi, Y Yaoita, D D Brown, Genomic organization and alternative promoter usage of the two thyroid hormone receptor beta genes in Xenopus laevis. Journal of Biological Chemistry. ,vol. 267, pp. 733- 738 ,(1992) , 10.1016/S0021-9258(18)48345-7
B. Le Douarin, A. L. Nielsen, J. M. Garnier, H. Ichinose, F. Jeanmougin, R. Losson, P. Chambon, A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors. The EMBO Journal. ,vol. 15, pp. 6701- 6715 ,(1996) , 10.1002/J.1460-2075.1996.TB01060.X
Michael Grunstein, Histone acetylation in chromatin structure and transcription Nature. ,vol. 389, pp. 349- 352 ,(1997) , 10.1038/38664
Jeffrey K. Tong, Christian A. Hassig, Gavin R. Schnitzler, Robert E. Kingston, Stuart L. Schreiber, Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex Nature. ,vol. 395, pp. 917- 921 ,(1998) , 10.1038/27699
B.P. Eliceiri, D.D. Brown, Quantitation of endogenous thyroid hormone receptors alpha and beta during embryogenesis and metamorphosis in Xenopus laevis. Journal of Biological Chemistry. ,vol. 269, pp. 24459- 24465 ,(1994) , 10.1016/S0021-9258(19)51106-1
Yun-Bo Shi, Amphibian Metamorphosis: From Morphology to Molecular Biology ,(1999)
Yun-Bo Shi, Jiemin Wong, Mukul Ranjan, Transcriptional repression of Xenopus TR beta gene is mediated by a thyroid hormone response element located near the start site. Journal of Biological Chemistry. ,vol. 269, pp. 24699- 24705 ,(1994) , 10.1016/S0021-9258(17)31447-3
Paul A. Wade, Peter L. Jones, Danielle Vermaak, Alan P. Wolffe, Purification of a histone deacetylase complex from Xenopus laevis: preparation of substrates and assay procedures. Methods in Enzymology. ,vol. 304, pp. 715- 725 ,(1999) , 10.1016/S0076-6879(99)04043-4
Xiao Hu, Mitchell A. Lazar, The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors Nature. ,vol. 402, pp. 93- 96 ,(1999) , 10.1038/47069
J K Tyler, M Bulger, R T Kamakaka, R Kobayashi, J T Kadonaga, The p55 subunit of Drosophila chromatin assembly factor 1 is homologous to a histone deacetylase-associated protein. Molecular and Cellular Biology. ,vol. 16, pp. 6149- 6159 ,(1996) , 10.1128/MCB.16.11.6149