Nebulized isotonic saline improves voice production in Sjögren's syndrome.

摘要: Objective This study examined the effects of a topical vocal fold hydration treatment on voice production over time. Study Design Prospective, longitudinal, within-subjects A (baseline), B (treatment), (withdrawal/reversal), (treatment) experimental design. Methods Eight individuals with primary Sjogren's syndrome (SS), an autoimmune disease causing laryngeal dryness, completed 8-week A-B-A-B experiment. Participants performed twice-daily audio recordings connected speech and sustained vowels then rated effort, mouth throat dryness. Two-week phases introduced 9-mL doses nebulized isotonic saline (0.9% Na+Cl−). Voice handicap patient-based measures SS severity were collected before after each 2-week phase. Connected analyzed using Cepstral Spectral Index Dysphonia (CSID). Acoustic ratings during baseline phase compared. Results Baseline CSID in mild-to-moderate range. improved by approximately 20% worsened withdrawal. Posttreatment values fell within normal-to-mild Similar patterns observed effort correlated significantly (P < .05). Conclusion Nebulized improves based acoustic severity. Future work should optimize formulations, dose, delivery methodologies for various patient populations. This lays groundwork future development to manage possibly prevent dehydration-related disorders. Level Evidence 2b. Laryngoscope, 125:2333–2340, 2015