The case for virus-induced type 1 diabetes.
作者： Isabella Spagnuolo , Aurora Patti , Guido Sebastiani , Laura Nigi , Francesco Dotta
DOI: 10.1097/MED.0B013E328362A7D7
关键词:
摘要: PURPOSE OF REVIEW Type 1 diabetes (T1D) results from the immune-mediated destruction of pancreatic insulin-producing cells because interaction among genetic susceptibility, immune system and environmental factor(s). A possible role viral infections in T1D pathogenesis has been hypothesized for some time; however, only most recent years, studies performed at molecular cellular level are starting to shed light on this issue. RECENT FINDINGS Studies animal models man have shown that viruses can indeed infect beta-cells, inducing islet inflammation functional damage. In addition, in-situ investigations tissue samples provided evidence addition adaptive response, innate immunity is involved whole pancreas (not its endocrine portion) infiltrated by phenomena. SUMMARY The established insulitic process increasing support contribution a proinflammatory scenario strongly suggestive may contribute beta-cell damage dysfunction, thus setting stage design antiviral strategies (e.g. vaccines drugs) aimed protecting beta-cells.
wkhealth.com参考文章(41)
T. Nakashima, T. Hayashi, Y. Yamamoto, T. Mizuno, Administration of interferon (IFN)-α exacerbates reovirus type-2-triggered autoimmune insulitis in DBA/1J mice. Scandinavian Journal of Immunology. ,vol. 76, pp. 378- 386 ,(2012) , 10.1111/J.1365-3083.2012.02754.X
Letizia Galleri, Guido Sebastiani, Francesco Vendrame, Fabio Arturo Grieco, Isabella Spagnuolo, Francesco Dotta, Viral Infections and Diabetes Advances in Experimental Medicine and Biology. ,vol. 771, pp. 252- 271 ,(2013) , 10.1007/978-1-4614-5441-0_20
K. T. Coppieters, A. Wiberg, S. M. Tracy, M. G. von Herrath, Immunology in the clinic review series: focus on type 1 diabetes and viruses: the role of viruses in type 1 diabetes: a difficult dilemma Clinical and Experimental Immunology. ,vol. 168, pp. 5- 11 ,(2012) , 10.1111/J.1365-2249.2011.04554.X
F. A. Grieco, G. Sebastiani, I. Spagnuolo, A. Patti, F. Dotta, Immunology in the clinic review series; focus on type 1 diabetes and viruses: how viral infections modulate beta cell function. Clinical and Experimental Immunology. ,vol. 168, pp. 24- 29 ,(2012) , 10.1111/J.1365-2249.2011.04556.X
Ai Tada, Akira Shimada, Taketo Yamada, Yoichi Oikawa, Yoshifumi Yamada, Yoshiaki Okubo, Junichiro Irie, Jeffrey A. Bluestone, Hiroshi Itoh, A Mimic of Viral Double-Stranded RNA Triggers Fulminant Type 1 Diabetes-like Syndrome in Regulatory T Cell-Deficient Autoimmune Diabetic Mouse Journal of Immunology. ,vol. 187, pp. 4947- 4953 ,(2011) , 10.4049/JIMMUNOL.1000837
Oskar Skog, Olle Korsgren, Gun Frisk, Modulation of innate immunity in human pancreatic islets infected with enterovirus in vitro Journal of Medical Virology. ,vol. 83, pp. 658- 664 ,(2011) , 10.1002/JMV.21924
Reiko Oka, Naoki Hiroi, Rika Shigemitsu, Mariko Sue, Yasuo Oshima, Mayumi Yoshida-Hiroi, Type 1 Diabetes Mellitus Associated with Pegylated Interferon-α Plus Ribavirin Treatment for Chronic Hepatitis C: Case Report and Literature Review. Clinical Medicine Insights: Endocrinology and Diabetes. ,vol. 4, pp. 39- 45 ,(2011) , 10.4137/CMED.S7815
Julien Diana, Yannick Simoni, Laetitia Furio, Lucie Beaudoin, Birgitta Agerberth, Franck Barrat, Agnès Lehuen, Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes Nature Medicine. ,vol. 19, pp. 65- 73 ,(2013) , 10.1038/NM.3042
Stephen A McCartney, William Vermi, Silvia Lonardi, Cristina Rossini, Karel Otero, Boris Calderon, Susan Gilfillan, Michael S Diamond, Emil R Unanue, Marco Colonna, None, RNA sensor–induced type I IFN prevents diabetes caused by a β cell–tropic virus in mice Journal of Clinical Investigation. ,vol. 121, pp. 1497- 1507 ,(2011) , 10.1172/JCI44005
A. Mercalli, V. Lampasona, K. Klingel, L. Albarello, C. Lombardoni, J. Ekström, V. Sordi, A. Bolla, A. Mariani, D. Bzhalava, J. Dillner, M. Roivainen, E. Bosi, L. Piemonti, No evidence of enteroviruses in the intestine of patients with type 1 diabetes Diabetologia. ,vol. 55, pp. 2479- 2488 ,(2012) , 10.1007/S00125-012-2591-4