Expression of FHL1 in gastric cancer tissue and its correlation with the invasion and metastasis of gastric cancer
作者： LiuKejian Guo , Yuanhong XuZhe
DOI:
关键词:
摘要: This study was performed to analyze the expression of four and a half LIM domains 1 (FHL1) in gastric carcinoma tissue its correlation with clini- copathological characteristics cancer. In addition, role FHL1 invasion metastasis cancer cells investigated provide an experimental basis for future treatments mRNA protein adja- cent normal mucosa were determined using RT-PCR western blots. Correlations expres- sion incidence, progression, clinicopatholog- ical analyzed. Changes metastatic potential MKN45 human observed after transient transfection eukaryotic vector containing full-length FHL1. Expression significantly lower than that adjacent (P \ 0.05). from patients who positive lymph node those negative Lower cor- related degrees differentiation, higher TNM stages, greater invasive The patterns similar surrounding detected no correlated However, independent patient's gender, age, tumor size ( Overexpression cell line resulted significant reduction invasiveness ability these as Transwell chamber assay decrease or loss may be invasiveness,
springer.com参考文章(27)
Mine Gulluoglu, Hasan Karanlik, N Faruk Aykan, Sezer Saglam, Emre Balik, Burak Sakar, A pilot study evaluating the safety and toxicity of epirubicin, cisplatin, and UFT (ECU regimen) in advanced gastric carcinoma Journal of gastrointestinal oncology. ,vol. 2, pp. 19- 26 ,(2011) , 10.3978/J.ISSN.2078-6891.2010.030
Gary Y Yang, Shane Hopkins, FDG PET imaging in the staging and management of gastric cancer Journal of gastrointestinal oncology. ,vol. 2, pp. 39- 44 ,(2011) , 10.3978/J.ISSN.2078-6891.2010.004
Rui-Yun Wu, G. N. Gill, LIM domain recognition of a tyrosine-containing tight turn. Journal of Biological Chemistry. ,vol. 269, pp. 25085- 25090 ,(1994) , 10.1016/S0021-9258(17)31502-8
Georg Lurje, Yan Ning, Susan Groshen, Cosima Lenz, Dongyun Yang, Thomas Winder, Alexandra Pohl, Heinz-Josef Lenz, Kayo Togawa, Felicitas Lenz, Andrew Hendifar, Survival of metastatic gastric cancer: Significance of age, sex and race/ethnicity Journal of gastrointestinal oncology. ,vol. 2, pp. 77- 84 ,(2011) , 10.3978/J.ISSN.2078-6891.2010.025
B Orr, A C P Riddick, G D Stewart, R A Anderson, O E Franco, S W Hayward, A A Thomson, Identification of stromally expressed molecules in the prostate by tag-profiling of cancer-associated fibroblasts, normal fibroblasts and fetal prostate. Oncogene. ,vol. 31, pp. 1130- 1142 ,(2012) , 10.1038/ONC.2011.312
Xun Li, Zhenyu Jia, Yongquan Shen, Hitoshi Ichikawa, Jonathan Jarvik, Robert G. Nagele, Gary S. Goldberg, Coordinate suppression of Sdpr and Fhl1 expression in tumors of the breast, kidney, and prostate Cancer Science. ,vol. 99, pp. 1326- 1333 ,(2008) , 10.1111/J.1349-7006.2008.00816.X
Dietmar E. Martin, Alexandre Soulard, Michael N. Hall, TOR Regulates Ribosomal Protein Gene Expression via PKA and the Forkhead Transcription Factor FHL1 Cell. ,vol. 119, pp. 969- 979 ,(2004) , 10.1016/J.CELL.2004.11.047
R. Feuerstein, X. Wang, D. Song, N. E. Cooke, S. A. Liebhaber, The LIM/double zinc-finger motif functions as a protein dimerization domain Proceedings of the National Academy of Sciences of the United States of America. ,vol. 91, pp. 10655- 10659 ,(1994) , 10.1073/PNAS.91.22.10655
Yongquan Shen, Zhenyu Jia, Robert G. Nagele, Hitoshi Ichikawa, Gary S. Goldberg, Src Uses Cas to Suppress Fhl1 in Order to Promote Nonanchored Growth and Migration of Tumor Cells Cancer Research. ,vol. 66, pp. 1543- 1552 ,(2006) , 10.1158/0008-5472.CAN-05-3152
M.J. Morgan, A.J.A. Madgwick, The Fourth Member of the FHL Family of LIM Proteins Is Expressed Exclusively in the Testis Biochemical and Biophysical Research Communications. ,vol. 255, pp. 251- 255 ,(1999) , 10.1006/BBRC.1999.0180