Unipolar depression in adolescents: clinical outcome in adulthood.

摘要: ABSTRACT Objective This study examined the longitudinal clinical course and adult sequelae of adolescent unipolar major depressive disorder (MDD) using a controlled design. Method Subjects were 28 adolescents (15.4 ± 1.3 years) with systematically diagnosed MOD 35 group-matched control subjects who participated in crosssectional electroencephalogram sleep neuroendocrine study. Using standardized instruments, interviewers blind to subjects' initial diagnoses conducted follow-up assessments 7.0 0.5 years later 94% original cohort. Results The depressed group showed high rates recurrence MDD episodes during interval period (69%). They also had elevated new-onset bipolar (19%). Twenty-three percent an diagnosis no additional after index assessment. rate new onset depression controls was 21%. Low socioeconomic status predicted group. recurrence(s) significant psychosocial morbidity, as evidenced by disruption interpersonal relationships dissatisfaction life decrease global functioning, compared both further never been psychiatrically ill. These deficits persisted remission from episode(s). Conclusions Adolescent predicts continued risk for recurrences persistence morbidity into adulthood. A sizable minority, however, have sustained periods associated good social adjustment.