Receiver array design for sonothrombolysis treatment monitoring in deep vein thrombosis.

摘要: High intensity focused ultrasound (HIFU) can disintegrate blood clots through the generation and stimulation of bubble clouds within thrombi. This work examined design a device to image for monitoring cavitation-based HIFU treatments deep vein thrombosis (DVT). Acoustic propagation simulations were carried out on multi-layered models human thigh using two patient data sets from Visible Human Project. The considerations included number receivers (32, 64, 128, 256, 512), their spatial positioning, effective angular array aperture (100° 180° about geometric focus). Imaging performance was evaluated source frequencies 250, 750, 1500 kHz. Receiver sizes fixed relative wavelength (pistons, diameter  =  λ/2) noise added at levels that scaled with receiver area. With 100° long axis size the  -3 dB main lobe ~1.2λ-i.e. order vessel diameter 250 kHz (~7 mm). Increasing span focus reduced by factor ~2. smaller achieved imaging higher came cost increased sensitivity phase aberrations induced during acoustic intervening soft tissue layers. signals, images could be reconstructed peak sidelobe ratios  <  -3 single-cycle integration times 250 750 kHz (NRx  ⩾  128). At 1500 kHz, longer and/or element counts required achieve similar ratios. Our results suggest modest receivers(i.e. NRx  =  128) arranged semi-cylindrical shell may sufficient enable passive (i.e. volumetric rates up 0.75 MHz) DVT.