The diversity-oriented synthesis of pteridines - achievements and potential for development.
作者： Colin J. Suckling
DOI: 10.1002/IUB.1148
关键词:
摘要: The importance of pteridines in the key cofactors, tetrahydrofolate and tetrahydrobiopterin, has encouraged development chemistry chemical biology pteridines. In order to investigate latter, versatile synthetic methods are required prepare designed relatives natural cofactors for use as potential drugs or biological probes. Recently, diversity-oriented synthesis become a particularly powerful approach related heterocyclic compounds. This article describes discusses available using radical, electrophilic, nucleophilic, organometal mediated substitution reactions.
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