Synthesis of the organic ligand of the molybdenum cofactor, in protected form

摘要: The organic ligand of the cofactor oxomolybdoenzymes has been synthesised in protected and masked form, 5. key steps conversion previously prepared 3, a 5-(2-amino-4-oxopteridin-6-yl)-4-(1,2-dihydroxyethyl)-1,3-dithiol-2-one were: formation pyran ring by reaction with chloroformate giving 8-amino-4-hydroxymethyl-6-(alkyloxycarbonyl)-5a,6,9,10-tetrahydro-[1,3]dithiolo[4′,5′:4,5]pyrano[3,2-g]pteridine-2,10-dione, 10, cyanoborohydride reduction 11,11a-imine, protection at N-11, finally alcohol into phosphate