Composition, synthesis, and use of new substituted pyran and pterin compounds
作者： Igor Pimkov , Partha Basu
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摘要: The present invention relates to substituted pterin compounds, their synthesis and use. In particular, the a new precursor compound its analogs for synthesizing analogs. These compounds are particularly suitable treating molybdenum cofactor deficiency.
lens.org 参考文章(13)
M.M. Wuebbens, K.V. Rajagopalan, Structural characterization of a molybdopterin precursor. Journal of Biological Chemistry. ,vol. 268, pp. 13493- 13498 ,(1993) , 10.1016/S0021-9258(19)38676-4
Guenter Schwarz, Jose Santamaria, Ralf Mendel, Jochen Reiss, Method for obtaining precursor Z and use thereof for the production of a means for therapy of human molybdenum cofactor deficiency ,(2005)
Kenneth M. Hartman, James D. Reedy, Sulfur-containing silane as coupling agents ,(2001)
Synthesis of the organic ligand of the molybdenum cofactor, in protected form Journal of The Chemical Society-perkin Transactions 1. pp. 3239- 3244 ,(2001) , 10.1039/B108579B
The synthesis of pyrano[2,3-b]quinoxalines related to molybdopterin Journal of The Chemical Society-perkin Transactions 1. pp. 3232- 3238 ,(2001) , 10.1039/B108576J
Ben Bradshaw, David Collison, C. David Garner, John A. Joule, Stable pyrano[2,3-b]quinoxalines and pyrano[2,3-g]pteridines related to molybdopterin Chemical Communications. pp. 123- 124 ,(2001) , 10.1039/B008544H
Ben Bradshaw, David Collison, C. David Garner, John A. Joule, Synthesis of 1,3-dithiol-2-ones as proligands related to molybdopterin. Organic and Biomolecular Chemistry. ,vol. 1, pp. 129- 133 ,(2003) , 10.1039/B209217D
José Angel Santamaria-Araujo, Berthold Fischer, Tanja Otte, Manfred Nimtz, Ralf R. Mendel, Victor Wray, Günter Schwarz, The Tetrahydropyranopterin Structure of the Sulfur-free and Metal-free Molybdenum Cofactor Precursor Journal of Biological Chemistry. ,vol. 279, pp. 15994- 15999 ,(2004) , 10.1074/JBC.M311815200
F. HAMMERSCHMIDT, S. SCHMIDT, The Phosphonate-Phosphate and Phosphate-Phosphonate Rearrangement and Their Applications. Part 5. On the Reaction of s-Butyllithium/TMEDA with Symmetrical Trialkyl Phosphates. ChemInform. ,vol. 29, ,(1998) , 10.1002/CHIN.199811196
Günter Schwarz, José Angel Santamaria-Araujo, Stefan Wolf, Heon-Jin Lee, Ibrahim M Adham, Hermann-Josef Gröne, Herbert Schwegler, Jörn Oliver Sass, Tanja Otte, Petra Hänzelmann, Ralf R Mendel, Wolfgang Engel, Jochen Reiss, Rescue of lethal molybdenum cofactor deficiency by a biosynthetic precursor from Escherichia coli Human Molecular Genetics. ,vol. 13, pp. 1249- 1255 ,(2004) , 10.1093/HMG/DDH136