Influence of Conformation on Immunochemical Properties of Proteins

摘要: The ability of foreign proteins to induce the production antibody has formed basis for both passive and active immunization humans animals against infectious diseases. Thus observation Behring Kitasato (1890) that cell-free sera rabbits mice, which were injected with inactivated diphtheria or tetanus toxin, capable neutralizing toxin led development antitoxin therapy. In early history immunology, attention was focused on methods inactivate a without affecting its antigenicity. use formalin proved be valuable discovery (Salkowski, 1898) had extensive application in commercial antitoxins (Glenny Sudmersen, 1921).