FDG-PET/CT response evaluation during EGFR-TKI treatment in patients with NSCLC.

作者: Matthijs H van Gool , Tjeerd S Aukema , Koen J Hartemink , Renato A Valdés Olmos , Harm van Tinteren

DOI: 10.4329/WJR.V6.I7.392

关键词:

摘要: Over recent years, [18F]-fluorodeoxyglucose positron emission tomography acquired together with low dose computed (FDG-PET/CT) has proven its role as a staging modality in patients non-small cell lung cancer (NSCLC). The purpose of this review was to present the evidence use FDG-PET/CT for response evaluation NSCLC, treated epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKI). All published articles from 1 November 2003 2013 reporting on 18F-FDG-PET during EGFR-TKI treatment NSCLC were collected. In total 7 studies, including data 210 eligible analyses. Our report shows that therapy potential targeted NSCLC. is associated clinical and radiologic survival. Furthermore monitoring can be performed early 1-2 wk after initiation treatment. Patients substantial decrease metabolic activity will probably benefit continued If does not occur within first weeks treatment, may spared (further) unnecessary toxicity ineffective Refining FDG-PET criteria help clinician decide continuation or discontinuation

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