Long-lasting effects of perinatal asphyxia on exploration, memory and incentive downshift

摘要: Perinatal asphyxia remains as one of the most important causes death and disability in children, without an effective treatment. Moreover, little is known about long-lasting behavioral consequences at birth. Therefore, main aim present study was to investigate motor, emotional cognitive functions adult asphyctic rats. Experimental subjects consisted rats born vaginally (CTL), by cesarean section (C+), or following 19 min (PA). At three months age, animals were examined a test battery including elevated plus maze, open field, Morris water incentive downshift procedure. Results indicated that groups did not differ anxiety-related behaviors, although large variability observed group therefore, results are completely conclusive. In addition, PA C+ showed deficit exploration new environments, but much lesser extent latter group. Spatial reference working memory impairments also found Finally, when downshifted from 32% 4% sucrose solution, attenuated suppression consummatory behavior These confirmed extended those reported previously alterations associated with acute around