OXANORBORNADIENE DERIVATIVES AND THEIR ANTICANCER ACTIVITIES

作者: Lu Aiping , Lin Chengyuan , Zhou Yongyun , Bian Zhaoxiang , Mu Huaixue

DOI:

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摘要: The present invention relates to chemical entities originated from natural sources and further synthesized for therapeutic uses. More particularly, the norcantharidin analogues by a transition metal-catalyzed alkynylation of oxanorbornadiene derivatives their antitumor effects.

参考文章(11)
Mariangela Rondanelli, Francesca Monteferrario, Simone Perna, Milena Anna Faliva, Annalisa Opizzi, Health-promoting properties of artichoke in preventing cardiovascular disease by its lipidic and glycemic-reducing action Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo. ,vol. 80, pp. 17- 26 ,(2013) , 10.4081/MONALDI.2013.87
Jun Hu, Qingjing Yang, Lu Yu, Jianbin Xu, Shanshan Liu, Chao Huang, Lin Wang, Yongyun Zhou, Baomin Fan, A study on the substituent effects of norbornadiene derivatives in iridium-catalyzed asymmetric [2 + 2] cycloaddition reactions Organic and Biomolecular Chemistry. ,vol. 11, pp. 2294- 2301 ,(2013) , 10.1039/C3OB27382B
Lesley-Ann Giddings, David J. Newman, Microbial natural products: molecular blueprints for antitumor drugs Journal of Industrial Microbiology & Biotechnology. ,vol. 40, pp. 1181- 1210 ,(2013) , 10.1007/S10295-013-1331-1
Dongwu Liu, Peiguo Shi, Xuan Yin, Zhiwei Chen, Xiuzhen Zhang, Effect of norcantharidin on the human breast cancer Bcap-37 cells. Connective Tissue Research. ,vol. 53, pp. 508- 512 ,(2012) , 10.3109/03008207.2012.694928
Chun-Chao Chang, Der-Zen Liu, Shyr-Yi Lin, Hong-Jen Liang, Wen-Chi Hou, Wei-Jan Huang, Chih-Hsiang Chang, Feng-Ming Ho, Yu-Chih Liang, Liposome encapsulation reduces cantharidin toxicity Food and Chemical Toxicology. ,vol. 46, pp. 3116- 3121 ,(2008) , 10.1016/J.FCT.2008.06.084
Andriy G. Golub, Volodymyr G. Bdzhola, Olga V. Ostrynska, Iaroslav V. Kyshenia, Vladislav M. Sapelkin, Andriy O. Prykhod’ko, Olexander P. Kukharenko, Sergiy M. Yarmoluk, Discovery and characterization of synthetic 4′-hydroxyflavones—New CK2 inhibitors from flavone family Bioorganic & Medicinal Chemistry. ,vol. 21, pp. 6681- 6689 ,(2013) , 10.1016/J.BMC.2013.08.013
Carlos E. Puerto Galvis, Leonor Y. Vargas Méndez, Vladimir V. Kouznetsov, Cantharidin-Based Small Molecules as Potential Therapeutic Agents Chemical Biology & Drug Design. ,vol. 82, pp. 477- 499 ,(2013) , 10.1111/CBDD.12180
YA-CHUN LEE, LIANG-MING LEE, CHIH-HSIN YANG, ANYA MAAN-YUH LIN, YI-CHIA HUANG, CHIA-CHI HSU, MENG-SHIAN CHEN, CHIN-WEN CHI, PEN-HUI YIN, CHENG-DENG KUO, JYH-FEI LIAO, HSIN-CHEN LEE, Norcantharidin suppresses cell growth and migration with enhanced anticancer activity of gefitinib and cisplatin in human non-small cell lung cancer cells Oncology Reports. ,vol. 29, pp. 237- 243 ,(2013) , 10.3892/OR.2012.2118
Bao-Min Fan, Qing-jing Yang, Jun Hu, Cai-ling Fan, Si-feng Li, Lu Yu, Chao Huang, Wing Wai Tsang, Fuk Yee Kwong, Asymmetric Hydroalkynylation of Norbornadienes Promoted by Chiral Iridium Catalysts Angewandte Chemie. ,vol. 51, pp. 7821- 7824 ,(2012) , 10.1002/ANIE.201203107
Wen-Wen Huang, Shih-Wei Ko, Huei-Yann Tsai, Jing-Gung Chung, Jo-Hua Chiang, Kuan-Tin Chen, Yen-Chen Chen, Hung-Yi Chen, Yuh-Fung Chen, Jai-Sing Yang, Cantharidin induces G2/M phase arrest and apoptosis in human colorectal cancer colo 205 cells through inhibition of CDK1 activity and caspase-dependent signaling pathways International Journal of Oncology. ,vol. 38, pp. 1067- 1073 ,(2011) , 10.3892/IJO.2011.922