EXPANSION CULTURE METHOD FOR NEPHRON PROGENITOR CELLS HAVING NEPHRON-FORMING CAPACITY
作者： Tanigawa Shunsuke , Nishinakamura Ryuichi
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摘要: The purpose of the present invention is to provide a method for expansion culture nephron progenitor cells while maintaining an undifferentiated state. Another cultured have nephron-forming ability. Yet another that makes it possible achieve excellent rate. provides culturing and increasing created from isolated mammalian or iPS using medium containing following compounds: (i) Wnt agonist; (ii) Notch inhibitor; (iii) Bmp; (iv) leukemia inhibitory factor; (v) Rock (vi) Fgf.
lens.org 参考文章(4)
Shunsuke Yuri, Masaki Nishikawa, Naomi Yanagawa, Oak D. Jo, Norimoto Yanagawa, Maintenance of Mouse Nephron Progenitor Cells in Aggregates with Gamma-Secretase Inhibitor PLOS ONE. ,vol. 10, pp. e0129242- ,(2015) , 10.1371/JOURNAL.PONE.0129242
A. C. Brown, D. Adams, M. de Caestecker, X. Yang, R. Friesel, L. Oxburgh, FGF/EGF signaling regulates the renewal of early nephron progenitors during embryonic development Development. ,vol. 138, pp. 5099- 5112 ,(2011) , 10.1242/DEV.065995
Atsuhiro Taguchi, Ryuichi Nishinakamura, Method of inducing kidney from pluripotent stem cells ,(2014)
U. Blank, A. Brown, D. C. Adams, M. J. Karolak, L. Oxburgh, BMP7 promotes proliferation of nephron progenitor cells via a JNK-dependent mechanism Development. ,vol. 136, pp. 3557- 3566 ,(2009) , 10.1242/DEV.036335