Possible involvement of stem cell factor and endothelin-1 in the emergence of pigmented squamous cell carcinoma in oral mucosa.
作者： Kazuhito Satomura , Reiko Tokuyama , Yasuhumi Yamasaki , Tetsuya Yuasa , Seiko Tatehara
DOI: 10.1111/J.1600-0714.2007.00587.X
关键词:
摘要: We present here the clinical, morphological and immunohistochemical features of a pigmented squamous cell carcinoma (SCC) in oral mucosa hard palate 76-year-old Japanese man. He underwent partial resection maxilla subsequent to radiotherapy. The tumor was typical, moderately well-differentiated SCC but had many melanocytes (melanocytosis) within it. Immunohistochemical analysis for stem factor (SCF) endothelin-1, both which are known stimulate proliferation differentiation melanocytes, revealed prominent expression factors neoplastic cells SCC, while non-pigmented showed little sign either factor. These findings strongly suggest that SCF endothelin-1 secreted by neoplasmic involved emergence rare variant SCC.
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