Multivariate analysis of occult lymph node metastasis as a prognostic indicator for patients with squamous cell carcinoma of the oral cavity

摘要: BACKGROUND The biologic aggressiveness of squamous cell carcinoma the oral cavity is reflected in its ability to metastasize regional cervical lymph nodes. Patients with clinically negative nodes are believed have a good prognosis; however, prognosis patients node metastasis occurring after excision or radiotherapy primary tumor poor. METHODS Univariate and multivariate analyses for occult (ONM) 172 were performed by authors elucidate clinical histologic risk factors enhance their predict ONM. A Cox proportional hazards model Hayashi's quantification theory type II used analyze prognostic determine probability ONM. RESULTS Using Cox's regression model, linked cancer specific survival selected: differentiation (P = 0.0330), mode invasion 0.0175), ONM 0.0433). Pathologically identified metastatic found 21.5 % cases studied (37 cases). The 5-year was 94.0 without metastasis, 51.0 < 0.0001, log rank test). most significant predictors each factors, descending order, were: invasion, intensity lymphocytic infiltration, degree differentiation, number mitotic figures, growth means II. presence absence 147 (85.5%) correctly predicted score at point intersection two curves, which -0.03. Further investigation revealed that 28 32 new differentiated accurately this diagnostic system. CONCLUSIONS The results current study suggest method analysis can establish reliable predictor ONM, thereby facilitating correct choices surgical procedures rates Cancer 1997; 80:351-6. © 1997 American Society.