Number and Migratory Activity of Circulating Endothelial Progenitor Cells Inversely Correlate With Risk Factors for Coronary Artery Disease

摘要: Recent studies provide increasing evidence that postnatal neovascularization involves bone marrow-derived circulating endothelial progenitor cells (EPCs). The regulation of EPCs in patients with coronary artery disease (CAD) is unclear at present. Therefore, we determined the number and functional activity 45 CAD 15 healthy volunteers. numbers isolated CD34/kinase insert domain receptor (KDR)-positive precursor were significantly reduced by approximately 40% 48%, respectively. To determine influence atherosclerotic risk factors, a factor score including age, sex, hypertension, diabetes, smoking, positive family history CAD, LDL cholesterol levels was used. factors correlated reduction EPC (R=-0.394, P=0.002) CD34-/KDR-positive (R=-0.537, P<0.001). Analysis individual demonstrated smokers had (P<0.001) (P=0.003). Moreover, associated (P=0.011). Most importantly, from also revealed an impaired migratory response, which inversely (R=-0.484, P=0.002). By multivariate analysis, hypertension identified as major independent predictor for migration (P=0.043). present study demonstrates impairment EPCs, CAD. Given important role ischemic tissue, decrease may contribute to vascularization full text this article available http://www.circresaha.org.