Cough reflex testing with inhaled capsaicin and TRPV1 activation in asthma and comorbid conditions.

摘要: A high parasympathetic tone leading to bronchoconstriction and neurogenic inflammation is thought have a major role in the pathogenesis of asthma. Transient receptor potential vanilloid 1 (TRPV1) hub almost all neuronal inflammatory signaling pathways. critical determinant inflammation, TRPV1 functions as sensor for detecting irritants lung by transmitting noxious stimuli central nervous system inducing release variety proinflammatory neuropeptides at peripheral terminals. Challenge with inhaled capsaicin, an exogenous agonist TRPV1, has been used measure sensitivity cough reflex. However, inhalation capsaicin also associated bronchoconstriction, mucus hypersecretion, vasodilatation, sensation dyspnea. Therefore, challenge expected other applications asthma comorbid conditions, such rhinitis gastroesophageal reflux disease, both which produce cough. Capsaicin established itself useful objective method evaluating airway hypersensitivity; however, it potentially valuable many situations, will be reviewed this paper.