Risk Factors for Second Malignancies Following Stem Cell Transplant
作者： Debra L. Friedman
DOI: 10.1007/978-3-540-76271-3_14
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摘要: Hematopoietic cell transplantation (HCT) offers potentially curative therapy for numerous malignancies, as well immunologic, hematologic and metabolic disorders. While many patients are cured of their primary disease, a proportion develops posttransplant (secondary) malignant neoplasms (SMN) [2, 19, 29]. Individuals treated with HCT may have been exposed to pre-transplant chemotherapy or radiotherapy, then additional cytotoxic part the preparative regimen transplantation, eventually, immune suppression. All these factors act alone in concert increase risk SMNs. Patients also be innately cancer susceptible genetic predisposition towards multiple malignancies. Potential SMN following hematopoietic stem listed Tables 14.1 14.2. Open image new window Table 14.1. General post-transplant malignancies Open 14.2. Post-transplant specific
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