Central nervous system vasculitis in cytomegalovirus infection.

摘要: Abstract A 51-year-old man received cyclophosphamide, vincristine, procarbazine and prednisone in the treatment of a small-cell undifferentiated lymphoma. Two years later, he developed rapidly progressive neurological syndrome characterized by decline alertness, deafness, blindness paraplegia. Examination his eyes revealed severe hemorrhagic chorioretinitis. Leg weakness was thought to be due transverse myelopathy at thoracic level. He had grand mal convulsion died from terminal bronchopneumonia. Autopsy examination sweeping destruction retina inclusion body The brain spinal cord showed multiple small infarcts accounting for deafness lesions were occlusive arteritis gray white matter. Veins also involved. Tissue surrounding foci necrosis contained cells with intranuclear intracytoplasmic bodies. Some Cowdry type bodies large, measuring 30 μm diameter located enlarged cells. Electron microscopy tissue disclosed virus particles compatible cytomegalovirus. subject cerebral ocular angiitis herpes infections is reviewed.