Carcinogenic Cr(VI) and the Nutritional Supplement Cr(III) Induce DNA Deletions in Yeast and Mice

摘要: Industrial Cr(VI) emissions contaminate drinking water sources across the U.S., and many people take Cr(III) nutritional supplements. is a human pulmonary carcinogen, but whether it carcinogenic in not known. Due to widespread exposure, imperative determine potential of Cr(III). DNA deletions other genome rearrangements are involved carcinogenesis. We determined effects as potassium dichromate chromium(III) chloride on frequencies measured with deletion assay Saccharomyces cerevisiae vivo pun reversion C57BL/6J pun/pun mice. Exposing yeast mice via significantly increased frequency deletions. quantified intracellular chromium concentrations tissue after exposure. Surprisingly, this revealed that more potent inducer than once absorbed. This study concludes both environmental contaminant supplement increase vitro vivo, when ingested water. (Cancer Res 2006; 66(7): 3480-4)