Robo-Enabled Tumor Cell Extrusion
作者： Helena E. Richardson , Marta Portela
DOI: 10.1016/J.DEVCEL.2016.12.008
关键词:
摘要: How aberrant cells are removed from a tissue to prevent tumor formation is key question in cancer biology. Reporting this issue of Developmental Cell, Vaughen and Igaki (2016) show that pathway with an important role neural guidance also directs extrusion epithelial tissues.
sci-hub.se 参考文章(10)
Shizue Ohsawa, Kaoru Sugimura, Kyoko Takino, Tian Xu, Atsushi Miyawaki, Tatsushi Igaki, Elimination of oncogenic neighbors by JNK-mediated engulfment in Drosophila. Developmental Cell. ,vol. 20, pp. 315- 328 ,(2011) , 10.1016/J.DEVCEL.2011.02.007
Brandon D Bunker, Tittu T Nellimoottil, Ryan M Boileau, Anne K Classen, David Bilder, The transcriptional response to tumorigenic polarity loss in Drosophila eLife. ,vol. 4, ,(2015) , 10.7554/ELIFE.03189
M C Schroeder, C-L Chen, K Gajewski, G Halder, A non-cell-autonomous tumor suppressor role for Stat in eliminating oncogenic scribble cells Oncogene. ,vol. 32, pp. 4471- 4479 ,(2013) , 10.1038/ONC.2012.476
M. Norman, K. A. Wisniewska, K. Lawrenson, P. Garcia-Miranda, M. Tada, M. Kajita, H. Mano, S. Ishikawa, M. Ikegawa, T. Shimada, Y. Fujita, Loss of Scribble causes cell competition in mammalian cells. Journal of Cell Science. ,vol. 125, pp. 59- 66 ,(2012) , 10.1242/JCS.085803
José Carlos Pastor-Pareja, Tian Xu, Dissecting Social Cell Biology and Tumors Using Drosophila Genetics Annual Review of Genetics. ,vol. 47, pp. 51- 74 ,(2013) , 10.1146/ANNUREV-GENET-110711-155414
Sergio Casas-Tintó, Fidel-Nicolás Lolo, Eduardo Moreno, None, Active JNK-dependent secretion of Drosophila Tyrosyl-tRNA synthetase by loser cells recruits haemocytes during cell competition Nature Communications. ,vol. 6, pp. 10022- 10022 ,(2015) , 10.1038/NCOMMS10022
Marisa M. Merino, Romain Levayer, Eduardo Moreno, Survival of the Fittest: Essential Roles of Cell Competition in Development, Aging, and Cancer Trends in Cell Biology. ,vol. 26, pp. 776- 788 ,(2016) , 10.1016/J.TCB.2016.05.009
Yoichiro Tamori, Emiko Suzuki, Wu-Min Deng, Epithelial Tumors Originate in Tumor Hotspots, a Tissue-Intrinsic Microenvironment. PLOS Biology. ,vol. 14, ,(2016) , 10.1371/JOURNAL.PBIO.1002537
Heike Blockus, Alain Chédotal, Slit-Robo signaling Development. ,vol. 143, pp. 3037- 3044 ,(2016) , 10.1242/DEV.132829
John Vaughen, Tatsushi Igaki, Slit-Robo Repulsive Signaling Extrudes Tumorigenic Cells from Epithelia Developmental Cell. ,vol. 39, pp. 683- 695 ,(2016) , 10.1016/J.DEVCEL.2016.11.015