Fusidic acid is an effective treatment against Toxoplasma gondii and Listeria monocytogenes in vitro, but not in mice

摘要: Fusidic acid is a bacteriostatic antibiotic that inhibits the growth of bacteria by preventing release translation elongation factor G (EF-G) from ribosome. The apicomplexan parasite Toxoplasma gondii has an orthologue bacterial EF-G can complement and necessary for virulence. been shown to be effective in tissue culture against related pathogen Plasmodium falciparum, current drug treatments T. are limited. We therefore investigated therapeutic value fusidic found was culture, but not mouse model infection. To determine whether this trend would occur another intracellular elicits T helper 1-type immune response, we tested efficacy bacterium Listeria monocytogenes. Similar its effects on gondii, L. monocytogenes vitro, mice. These findings highlight necessity vivo follow-up studies validate vitro investigations.