Effect of verapamil on left ventricular hypertrophy induced by isoproterenol

摘要: PURPOSE We evaluated whether verapamil (VERA) has a protective effect on left ventricular hypertrophy (LVH) induced by Isoproterenol (ISO) in rat. METHODS Seventy two male adult rats were divided four groups and treated accordingly during eight days: Control (CON), VERA (10 mg/kg), ISO (0.3 mg/kg) + ISO. It was measured 10 animals from each group heart rate, blood pressure, ventricle dry weight ratio between (LVW) rat weight. Samples taken the to be examined light microscopy. RESULTS LVW of CON 0.145 g, 0.144 with 0.201 0.148 g. The difference others statistically significant (P < 0.05). LVW/W also showed similar result. myocardial pattern collagen content increase. In it found (ISO 97% vs 87%; p 0.001) increased content. CONCLUSION prevents deleterious effects myocardium. Probably this action is due prevention proliferation tissue.