Association of tumor necrosis factor alpha-308 promoter polymorphism with spondyloarthritides patients in Colombia.
作者： Consuelo Romero-Sánchez , J Londoño , G Delgado , DA Jaimes , J De Avila
DOI: 10.1007/S00296-011-1883-1
关键词:
摘要: The pathogenesis of SpA is considered to be a complex and multi-factorial process and, similar other autoimmune diseases, includes the activity proinflammatory cytokines such as TNF alpha. Our study compared -308 promoter polymorphism alpha with levels, HLA-B27 status, age at onset symptoms, subtype clinical degree in Colombian patients healthy subjects (HS). Comparisons alpha-308A genotype among HS (P = 0.004), uSpA 0.040), ReA 0.001), were significantly different AS 0.110), alleles for SpAs 0.007) between controls. Initial exploratory analyses demonstrated that alpha-308 SNP frequencies population studied. Furthermore, there was no significant correlation functional index, serum level or HLA B27 status. Allele frequencies, on hand, correlated index.
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