Ankylosing Spondylitis: From Cells to Genes

摘要: Ankylosing spondylitis (AS) is a chronic inflammatory disease of unknown etiology, though it considered an autoimmune disease. HLA-B27 the risk factor most often associated with AS, and although mechanism involvement unclear, subtypes other features relationship between AS have been studied for years. Additionally, key role IL-17 Th17 cells in autoimmunity inflammation suggests that latter cytokines involved their generation could play pathogenesis this Recent studies described sources IL-23, as well characterization diseases. Other cells, such NK regulatory T implicated evaluated to ascertain possible AS. Moreover, several polymorphisms, mutations deletions proteins, protein-coding regions, promoter regions different genes immune responses discovered genetic linkages In review, we analyze suggested mechanisms its while also focusing on response identification