Association between MDM2 SNP309 and endometrial cancer risk: A PRISMA-compliant meta-analysis.

摘要: BACKGROUND Murine double minute 2 homolog (MDM2) plays an important role in the downregulation of P53 tumor suppressor gene. MDM2 inhibits transcriptional activity and thereby results accelerated formation. Overexpression has been found several cancer types including endometrial cancer. SNP309 is located promoter region contributes to overexpression MDM2. The association between polymorphism risk investigated studies; however, conclusion remains controversial. OBJECTIVES We performed present meta-analysis give a comprehensive susceptibility. METHODS conducted literature research on PubMed, Embase, Cochrane Library, OVID, Web Science, Wan Fang, CNKI, CQVIP databases up July 31, 2018. Newcastle-Ottawa scale was used assess quality studies. evaluated strength by combining odds ratios (ORs) 95% confidence intervals (CIs) 5 different genetic models under fixed-effect model or random-effect model. further subgroup analysis ethnicity, source control, histological type, clinical grade, stage tumor. Sensitivity publication bias were also performed. RESULTS Nine eligible studies finally included our meta-analysis. increased allele (OR: 1.23, CI: 1.06-1.41, P = .005), homozygote 1.43, 1.13-1.81, P = .003) recessive 1.55, 1.17-2.04, P = .002). Subgroup suggested similar elevated both Asians Caucasians. identified strong enhanced susceptibility endometrioid group 2.13, 1.28-3.54, P = .004) Type I 1.89, 1.25-2.86, P = .002) dominant no significant according Egger's test. CONCLUSIONS Our that significantly, especially cancer, indicating could serve as potential diagnostic factor marker for