Effects of integrins and integrin αvβ3 inhibitor on angiogenesis in cerebral ischemic stroke
作者： Jia-jia Bi , Li Yi
DOI: 10.1007/S11596-014-1274-4
关键词:
摘要: Integrins such as αvβ3, α5β1 play a key role in angiogenesis regulation, invasion and metastasis, inflammation, wound healing, etc. The up-regulation of integrin αvβ3 after cerebral ischemic stroke can promote angiogenesis, which turn improves functional recovery. In addition, the inhibitor block blood-brain barrier (BBB) leakage induced by vascular endothelial growth factor (VEGF) also reduce inflammatory reaction, decrease deposition fibrinogen. Other studies showed that is not essential revascularization. Therefore, effect whole process brain function recovery merits further study.
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