The Mechanisms of PML-Nuclear Body Formation

摘要: PML nuclear bodies (NBs) are structures that have been implicated in processes such as transcriptional regulation, genome stability, response to viral infection, apoptosis, and tumor suppression. has found be essential for the formation of NBs, these do not form Pml null cells, although add back fully rescues their formation. However, basis a structural role is unknown. We demonstrate contains SUMO binding motif independent its SUMOylation sites surprisingly necessary PML-NB RING domain critical propose model whereby noncovalent SUMOylated through constitutes nucleation event subsequent recruitment proteins and/or containing motifs NBs.