New Experimental Models of Skin Homeostasis and Diseases
作者： F. Larcher , J. Espada , B. Díaz-Ley , P. Jaén , A. Juarranz
DOI: 10.1016/J.ADENGL.2014.11.013
关键词:
摘要: Homeostasis, whose regulation at the molecular level is still poorly understood, intimately related to functions of epidermal stem cells. Five research groups have been brought together work on new in vitro and vivo skin models through SkinModel-CM program, under auspices Spanish Autonomous Community Madrid. This project aims analyze DNA methyltransferase 1, endoglin, podoplanin cell activity, homeostasis, cancer. These include 3-dimensional organotypic cultures, immunodeficient skin-humanized mice, genetically modified mice. Another aim program use mice model dermatoses such as Gorlin syndrome xeroderma pigmentosum order optimize protocols for photodynamic therapy.
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