Exosomes function in antigen presentation during an in vivo Mycobacterium tuberculosis infection

摘要: Mycobacterium tuberculosis-infected macrophages and dendritic cells are limited in their ability to present antigen CD4+ T suggesting that other mechanism of presentation driving the robust cell response observed during an M. tuberculosis infection. These mechanisms could include antigens apoptotic bodies, necrotic debris, exosomes or even release non-vesicular from infected cells. However, there is data support any these as important activation vivo. In study we use Rab27a-deficient mice which show diminished trafficking mycobacterial components well strains express recombinant proteins traffic fail exosomes. We released a mouse infection contribute significantly its response. finding imply function promote immunity bacterial source extracellular antigen.